(I ) Sickle cell disease (II) Metheglobinemia, beta-globin type (III) Beta thalassemia: thalassemia major and thalassemia intermedia

All three disorders affect the production or function of hemoglobin.

Symptoms of the different disorders are as follows: (1) Anemia, repeated infections, periodic episodes of pain. (2) Bluish appearance of the skin, mucous membranes, or area under the fingernails. (3) Anemia, pale skin, weakness, fatigue, risk of abnormal blood clots, enlarged spleen, liver, and heart.